Product Name: SS31 (Elamipretide) CAS Number: 736992-21-5 Molecular Formula: C₃₂H₄₉N₉O₅ Amino Acid Sequence: H-D-Arg-(2′,6′-dimethyl-Tyr)-Lys-Phe-NH₂ Purity: ≥99% (HPLC verified) Formulation: Lyophilized powder (typically available in 10mg, 50mg vials or custom specifications)
🔬 Key Characteristics
SS31 is a synthetic mitochondria-targeted peptide designed to penetrate cell membranes and localize specifically to mitochondrial inner membranes. As a derivative of the tetrapeptide elamipretide, it exhibits high affinity for cardiolipin—a critical phospholipid in mitochondrial structure—and acts as a potent modulator of mitochondrial function in preclinical research.
⚙️ Mechanism of Action
Mitochondrial Protection: Stabilizes mitochondrial membrane integrity by interacting with cardiolipin, preventing lipid peroxidation and maintaining the proton gradient essential for ATP production.
Oxidative Stress Reduction: Scavenges reactive oxygen species (ROS) and inhibits mitochondrial permeability transition pore (mPTP) opening, mitigating oxidative damage in stressed cells.
Energy Metabolism Enhancement: Improves mitochondrial respiration efficiency by optimizing electron transport chain function, particularly in tissues with high energy demand (brain, heart, skeletal muscle).
📊 Research Applications
Neuroprotection: Investigated in models of neurodegenerative diseases (Alzheimer’s, Parkinson’s) and ischemic stroke, where mitochondrial dysfunction drives neuronal loss.
Cardioprotection: Studied for potential in heart failure, ischemia-reperfusion injury, and cardiomyopathies by preserving cardiac mitochondrial function.
Aging & Metabolic Disorders: Evaluated in age-related metabolic decline models, including insulin resistance and sarcopenia, due to its role in cellular energy homeostasis.
💡 Product Features
Targeting Precision: Mitochondria-specific localization enables focused action without systemic off-target effects in research settings.
Stability: Lyophilized form ensures long-term stability under -20°C storage; reconstitutes readily in aqueous or organic solvents (e.g., DMSO).
Purity: ≥99% HPLC purity suitable for in vitro, ex vivo, and preclinical in vivo studies.
⚠️ Disclaimer
For Research Use Only: Not approved for human or veterinary clinical use. Handling requires compliance with peptide research protocols, including proper storage and biosafety measures.
