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Ara-290 10 mg*10vials Kit

Ara-290 10 mg*10vials Kit

$77.00

Description

🧪 Product Profile: ARA-290 (Cibinetide)

Chemical Name: Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH
Synonyms: Cibinetide; EPO-derived peptide; ARA290 acetate
CAS Number: 1208243-50-8
Molecular Formula: C₅₁H₈₄N₁₆O₂₁
Molecular Weight: 1257.31 g/mol
Form: White to off-white lyophilized powder
Purity: ≥98% (HPLC); single impurity ≤2.0%
Presentation: 1g/vial or custom packaging; sealed under nitrogen atmosphere

🔬 Mechanism of Action

ARA-290 is a synthetic peptide derived from erythropoietin (EPO) that selectively activates the EPO/CD131 heteroreceptor complex without stimulating erythropoiesis:

  • Receptor Specificity: Binds to the common β-chain (CD131) shared by EPO, IL-3, and GM-CSF receptors, triggering neuroprotective signaling cascades.
  • Intracellular Pathways: Activates JAK2/STAT3 and PI3K/Akt pathways to promote:
    • Anti-inflammatory cytokine release (IL-10 upregulation)
    • Oxidative stress reduction (Nrf2/HO-1 activation)
    • Neuronal survival (Bcl-2 expression; caspase-3 inhibition)
  • Blood-Brain Barrier Penetration: Low molecular weight (1.26 kDa) enables passive diffusion across the BBB, reaching CNS tissues at therapeutic concentrations.

🧠 Research Applications

Primarily used as a tool compound in preclinical models of neurological disorders:

  • Neurodegenerative Diseases: Alzheimer’s (tau phosphorylation inhibition), Parkinson’s (dopaminergic neuron protection), and ALS (motor neuron survival).
  • Ischemic Stroke: Reduces infarct volume by 40-50% in rodent MCAO models via anti-apoptotic mechanisms.
  • Neuropathic Pain: Modulates spinal microglia activation (reduced TNF-α/IL-1β levels) in CCI and SNI models.
  • Traumatic Brain Injury: Improves functional recovery by enhancing synaptic plasticity (BDNF upregulation).

📊 Physical & Chemical Properties

Property Specification
Density 1.56±0.1 g/cm³ (predicted)
pKa 2.90±0.10 (carboxylic acid group)
Solubility Soluble in DMSO (50 mg/mL); slightly soluble in water
Stability Stable for 24 months at -20°C under argon; avoid repeated freeze-thaw cycles
Amino Acid Sequence Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser

⚙️ Handling & Storage

  • Reconstitution: Dissolve in sterile DMSO or 0.1% TFA aqueous solution to prepare stock solutions (1-10 mM).
  • Storage Conditions: Store unopened vials at -20°C to -80°C; after reconstitution, aliquot and store at -80°C for up to 3 months.
  • Safety Notes: For research use only (RUO); wear PPE (gloves, goggles) during handling; avoid inhalation or skin contact.

📌 Key Supplier Specifications

  • Impurity Profile: Acetate content 5.0-12.0%; moisture ≤10.0% (Karl Fischer).
  • Endotoxin Level: ≤50 EU/mg (LAL assay).
  • Peptide Content: ≥80.0% (by amino acid analysis).
[WPSM_AC id=3213]

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