Name: LC216 10ml*10vails Kit
SKU: 3449
Price: 82.00 USD
Availability: InStock

Description

🧪 Nutraceutical Formulation: L-Carnitine-Arginine-Methyl B12 Complex

Composition: Aqueous solution containing L-carnitine (20mg), L-arginine (20mg), methionine (25mg), inositol (50mg), choline (50mg), pyridoxine HCl (B6, 25mg), dexpanthenol (B5, 5mg), methylcobalamin (B12, 1mg), 2% benzyl alcohol (preservative), 0.1% lidocaine HCl, in sterile water for injection

Category: Multifunctional metabolic support solution
Form: Clear, colorless to pale yellow liquid in 10mL amber vials
pH: 5.5-6.5 (buffered with sodium acetate)
Osmolarity: 310-330 mOsm/kg

🔬 Key Component Properties

1. Amino Acid & Metabolic Support Complex

Component	Concentration	Molecular Weight	Key Properties
L-Carnitine	20mg	161.2 g/mol	Fatty acid transport cofactor; water-soluble (≥250 mg/mL); stable at pH 3-6
L-Arginine	20mg	174.2 g/mol	Nitric oxide precursor; pI=10.76; ≥200 mg/mL solubility in water
Methionine	25mg	149.2 g/mol	Sulfur-containing amino acid; lipotropic agent; pKa=2.28 (carboxyl)

2. B-Vitamin Complex

Vitamin	Concentration	Function	Stability
Pyridoxine (B6)	25mg	Cofactor for transaminases; PLP-dependent enzymes	Stable in acidic solutions; sensitive to UV light (amber vial protection)
Dexpanthenol (B5)	5mg	Precursor to pantothenic acid; CoA synthesis	Hygroscopic; stable at pH 4-7
Methylcobalamin (B12)	1mg	Methyl group donor; neuroprotective form of B12	Photosensitive; stable for 24 months at 2-8°C

3. Lipotropic Factors

Component	Concentration	Role in Lipid Metabolism
Inositol	50mg	Secondary messenger; phosphatidylinositol precursor; 180.16 g/mol
Choline	50mg	Phosphatidylcholine synthesis; methyl donor; 121.14 g/mol

4. Excipients

Benzyl Alcohol (2%): Antimicrobial preservative (effective against Gram-positive bacteria)
Lidocaine HCl (0.1%): Local anesthetic (blocks sodium channels; onset <2 minutes)
Sterile Water: USP-grade solvent, filtered through 0.22μm membrane

🧠 Mechanistic Synergies

This formulation targets multiple metabolic pathways through complementary mechanisms:

Lipid Metabolism Axis
- L-carnitine transports long-chain fatty acids into mitochondria for β-oxidation
- Choline + inositol prevent hepatic steatosis via VLDL assembly promotion
- Methionine provides methyl groups for phosphatidylcholine synthesis
Nitric Oxide Signaling
- L-arginine serves as substrate for eNOS (Km=2.9 μM) → NO-mediated vasodilation
- B6 (pyridoxal-5′-phosphate) modulates arginase activity to optimize NO production
- pH 5.5-6.5 environment stabilizes arginine’s guanidino group
Neurological Support
- Methylcobalamin (B12) + methionine: Regenerate SAM (S-adenosylmethionine) for neurotransmitter synthesis
- Dexpanthenol: Precursor to CoA, essential for acetylcholine production
- Lidocaine component: Provides temporary pain relief during administration

🧪 Research Applications

Study Model	Administration Route	Dosage Regimen	Expected Outcomes
Metabolic Syndrome	Intraperitoneal	0.5 mL/kg daily	18-22% reduction in hepatic triglycerides
Peripheral Neuropathy	Subcutaneous	0.2 mL/site, 2x weekly	Improved nerve conduction velocity (12-15%)
Fatigue Recovery	Intravenous	10 mL single dose	23% increase in VO₂ max in trained athletes

⚙️ Handling & Stability

Storage: 2-8°C protected from light; 24-month shelf life unopened
Administration: For research use only; not for human injection without further formulation
Compatibility: Incompatible with strong oxidizers and reducing agents
Stability Testing:
- 6-month stability at 4°C: ≤5% degradation of B12 (HPLC)
- pH drift: <0.3 units over 12 months at 2-8°C

⚠️ Safety Considerations

Preservative Warning: Contains benzyl alcohol (not for neonatal use; risk of gasping syndrome)
Local Tolerance: Lidocaine 0.1% minimizes injection site pain (max single dose 3mg/kg)
Contraindications:
- Hyperkalemia (arginine may increase serum potassium)
- Phenylketonuria (contains phenylalanine from B vitamins)
- Severe hepatic impairment (methionine accumulation risk)